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My research is focused on understanding the role of two G protein-coupled receptors in the regulation of anti-microbial functions of neutrophils. These receptors are: the histamine four receptor (H₄R) and the proton-regulated receptor GPR68. During chronic lung inflammation, histamine level may raise in lung fluids and tissues. In parallel the pH drops due to the high metabolism of bacteria. Histamine and acidic conditions may impair neutrophil anti-microbial functions by controlling the activity of the H₄R and GPR68, respectively.